At the Chennai International Fashion Week (CIFW) in December 2009, she appeared as a showstopper for designer Ishita Singh's spring-summer indigenous collection of 2010, showcasing the best of Indian and Western dresses.
The same year, she made her Tamil debut as the teenage girl Harini in Boys, a story about five teenagers having stereotypical teen-boy fantasies.
The movie, though noted for its vulgar sexual content, was a box-office success, In 2004, Genelia appeared in her second Bollywood movie, Masti.
Genelia with her family at the CNBC Awaaz consumer awards in 2010.
Seen here from left to right is her father Neil D'Souza, her mother Jeanette D'Souza, herself, and at the extreme right, her brother Nigel D'Souza. Her mother Jeanette D'Souza was a managing director of the Pharma Multinational corporation.
The comedy focuses on three close friends who reunite after three years, but are now married and are being harassed by their wives.
Genelia portrayed the character of one of the wives.
She appeared alongside Shahid Kapoor on the fourth episode of Tere Mere Beach Mein, a celebrity chat show, hosted by Farah Khan.
The theme of the show was "Second Innings", since both D'Souza and Kapoor had the same history of failures initially and success later in their acting careers.
Several Bollywood actors and the South Indian film industry had boycotted the event, over the alleged killing of Tamilian civilians at the height of the conflict between the Sri Lanka Army and the Liberation Tigers of Tamil Eelam (LTTE) in 2009.